[Analysis the relation of adults HBV vicinal failure and T cell subset, HLA-DR rang gene phenotype] Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology [Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi] Journal article | | Title | [Analysis the relation of adults HBV vicinal failure and T cell subset, HLA-DR rang gene phenotype] | | Author(s) | Hu DB, Liu SK, Zhao LL, Xu AP, Hong YZ, Cao PY | | Institution | Center for Disease Control of Ninghai County, Ninghai 315600, Zhejiang, China. | | Source | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2009 Feb; 23(1):17-9. | | Abstract | OBJECTIVE: To study and explore the relativity of adults HBV vicinal failure and HLA-DR, T cell subset, trace viruses infection. To accumulate date for formulating preventing adult HBV infection prophylactic-therapeutic measures.
METHODS: Select 20 adults randomly who had vaccinated with 10 microgYDV and produced anti-HBS successfully, and another 20 hadn't produced anti-HBs to form two groups-defeated group and contral group. Blood samples from two groups were taken for detecting the level of DR range gene phenotype: T cell subset, white blood cell HLA-DR, HLA-B27, HLA DRB1 * 07, DRB1* 04, DRB1 * 1001, DQB1 * 0401 and so on.
RESULTS: The level of CD4(-)/CD8(-) is lower in the infection group than in healthy group. But the average level of HLA-DR and HLA-B27 is higher in the infection group. The differences of HLA DRB1 * 07 gene frequency between two groups were significant (P <0.05), but the levels of CD3, CD4, CD8, CD7, CD4/CD8 and HLA DRB1 * 04, DRB1 * 1001, DQB1 * 0401 were not significant.
CONCLUSION: The failure of HBV vaccination on adults may have relation to HLA-DR, HLA-B27, HLA DRB1 * 07, CD4(-)/CD8(-), etc. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19799007 |
|
|
| |
Advertise on this site.
| | |
|
